diff --git a/gcc/ipa-sra.cc b/gcc/ipa-sra.cc
index 3fee8fb22ce..21d281a9756 100644
--- a/gcc/ipa-sra.cc
+++ b/gcc/ipa-sra.cc
@@ -3074,6 +3074,8 @@ struct caller_issues
   cgraph_node *candidate;
   /* There is a thunk among callers.  */
   bool thunk;
+  /* Set if there is at least one caller that is OK.  */
+  bool there_is_one;
   /* Call site with no available information.  */
   bool unknown_callsite;
   /* Call from outside the candidate's comdat group.  */
@@ -3116,6 +3118,8 @@ check_for_caller_issues (struct cgraph_node *node, void *data)
 
       if (csum->m_bit_aligned_arg)
 	issues->bit_aligned_aggregate_argument = true;
+
+      issues->there_is_one = true;
     }
   return false;
 }
@@ -3170,6 +3174,13 @@ check_all_callers_for_issues (cgraph_node *node)
       for (unsigned i = 0; i < param_count; i++)
 	(*ifs->m_parameters)[i].split_candidate = false;
     }
+  if (!issues.there_is_one)
+    {
+      if (dump_file && (dump_flags & TDF_DETAILS))
+	fprintf (dump_file, "There is no call to %s that we can modify.  "
+		 "Disabling all modifications.\n", node->dump_name ());
+      return true;
+    }
   return false;
 }
 
diff --git a/gcc/testsuite/gcc.dg/ipa/pr110276.c b/gcc/testsuite/gcc.dg/ipa/pr110276.c
new file mode 100644
index 00000000000..5a1e2f3fb1c
--- /dev/null
+++ b/gcc/testsuite/gcc.dg/ipa/pr110276.c
@@ -0,0 +1,15 @@
+/* { dg-do compile } */
+/* { dg-options "-O2" } */
+
+typedef long (*EFI_PCI_IO_PROTOCOL_CONFIG)();
+typedef struct {
+  EFI_PCI_IO_PROTOCOL_CONFIG Read;
+} EFI_PCI_IO_PROTOCOL_CONFIG_ACCESS;
+typedef struct {
+  EFI_PCI_IO_PROTOCOL_CONFIG_ACCESS Pci;
+} EFI_PCI_IO_PROTOCOL;
+int init_regs_0;
+static void __attribute__((constructor)) init(EFI_PCI_IO_PROTOCOL *pci_io) {
+  if (init_regs_0)
+    pci_io->Pci.Read();
+}