diff --git a/lisp/progmodes/python.el b/lisp/progmodes/python.el
index 692d915f8f8..227be64b5b0 100644
--- a/lisp/progmodes/python.el
+++ b/lisp/progmodes/python.el
@@ -4549,6 +4549,9 @@ def __PYTHON_EL_native_completion_setup():
             readline.parse_and_bind('tab: complete')
             # Require just one tab to send output.
             readline.parse_and_bind('set show-all-if-ambiguous on')
+            # Avoid ANSI escape characters in the output
+            readline.parse_and_bind('set colored-completion-prefix off')
+            readline.parse_and_bind('set colored-stats off')
             # Avoid replacing common prefix with ellipsis.
             readline.parse_and_bind('set completion-prefix-display-length 0')