diff --git a/test/lisp/progmodes/python-tests.el b/test/lisp/progmodes/python-tests.el
index f871b7bc7d9..3efc28c7edc 100644
--- a/test/lisp/progmodes/python-tests.el
+++ b/test/lisp/progmodes/python-tests.el
@@ -4566,6 +4566,11 @@ import abc
 
 (ert-deftest python-ffap-module-path-1 ()
   (skip-unless (executable-find python-tests-shell-interpreter))
+  ;; Skip the test on macOS, since the standard Python installation uses
+  ;; libedit rather than readline which confuses the running of an inferior
+  ;; interpreter in this case (see bug#59477 and bug#25753).
+  (skip-unless (not (eq system-type 'darwin)))
+  (trace-function 'python-shell-output-filter)
   (python-tests-with-temp-buffer-with-shell
    "
 import abc